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This wide variation reflects differences in starting weight, baseline metabolism, dose escalation schedule, and individual physiology rather than medication failure

The data supports benefits, the mechanism provides differentiation, and the category framework avoids regulatory exposure

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examined the safety of intraarticular injections of recombinant human IL-1Ra in patients with knee OA, which was well tolerated and did not induce any acute inflammatory reaction in OA patients (238)

Expression of SBP2 , a factor recognizing SECIS element, had a positive correlation with GPX1 and GPX4 expression and antioxidant capacity in chondrocytes 96