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5 The condition is further compounded by comorbidities, such as hypertension, diabetes and chronic kidney disease, all of which contribute to an increased risk of adverse cardiovascular events

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2 Preclinical evidence and mechanistic studies This section summarizes the key in vitro and in vivo findings from preclinical studies of major classes of natural metabolites from TCMs with cardioprotective effects, and discusses the key molecular targets and pathways by which these natural metabolites exert their cardioprotective effects