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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

The peptide has shown activity in models of neurological injury, though again, these results are primarily from animal studies rather than human trials

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Viennois, E., et al