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This family of enzymes is central to the respiratory burst in immune responses and the generation of H 2 O 2 as a second messenger in cellular signalling, development, and environmental sensing across kingdoms 1,2

The dry weight of plants decreased as compared to control plants

For a patient with ME/CFS, this biological mechanism perfectly mirrors the experience of post-exertional malaise (PEM)

The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins allows Prx to function as a sensor of H 2 O 2 (Rhee et al., 2012)

Disulfiram/copper induce ferroptosis in triple-negative breast cancer cell line MDA-MB-231