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Even if potency loss isn't visible, reduced effectiveness may result in slower weight loss progress or inconsistent hunger suppression

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However, the issue lies with insurance coverage

However, it's important to note that evidence in autoimmune disease populations specifically remains limited, with no randomised controlled trials targeting autoimmune disease outcomes with semaglutide

However, some patients may be advised to withhold Rybelsus temporarily, particularly if they: Are experiencing significant gastrointestinal side effects Are in the dose-escalation phase of treatment Have known gastroparesis or delayed gastric emptying Are undergoing procedures with higher aspiration risk If your clinical team does recommend withholding Rybelsus, they will provide specific instructions about when to stop