This means that their findings may not be fully generalizable to other settings. They also note that their records only show whether a medication was dispensed to a patient and not whether they took it as prescribed
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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)
A public comment period runs through June 29, 2026, and the FDA will consider submitted comments before issuing a final determination
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