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This explains why some patients experience: Temporary bloating or joint discomfort from fluid shifts Increased hunger due to ghrelin pathway activation Changes in blood sugar regulation in susceptible individuals Patients with diabetes, insulin resistance, or other metabolic conditions require medical evaluation and appropriate monitoring before and during treatment

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The inhibitory effect of propranolol on the HepG2.2.15 liver cancer cell line is weaker than on HepG2, possibly due to the expression of HBV in HepG2.2.15, with no significant toxicity on the normal liver cell line HL-7702 87