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Cancer-associated adipocytes exhibit phenotypic changes including secretion of the lipids, inflammatory cytokines, and an imbalance in adipokine signaling pathways, such as the upregulation of leptin and downregulation of adiponectin, which promote tumor proliferation and invasion (123)

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doi: 10.1016/j.msec.2020.111660

GIP, specifically, reduces appetite by affecting the brain