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Furthermore, research has shown that fasting, CR, and caloric restriction mimetics (CRMs) can promote T-cell-mediated tumor cytotoxicity, alter NK cell function, and potentially trigger immunogenic cell death, thereby stimulating cancer immunosurveillance pathways

However, because Nrf2 activation primarily affects the lens epithelium and cortex, alternative strategies are required to replenish glutathione in the lens nucleus

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Understanding how to maximize value while maintaining protocol effectiveness helps justify the expense and avoid waste