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doi: 10.1210/jc.2011-1256

TABLE 1 1 2 3 Arrows 1 -3 denote pb = peptide bond

Some laboratory studies and theories suggest that high-dose vitamin C may create an environment that is challenging to cancer cells

However, UBXD8, a protein in the ER-associated degradation (ERAD) pathway, can bind PNPLA2, preventing the interaction with ABHD5, thereby segregating PNPLA2 to valosin-containing protein (VCP)/p97 segragrase that promotes extraction and subsequent Ub-dependent degradation (132) (Figure 1)

The most accessible models are models that can readily be used to screen several therapeutics at once before moving in to living organisms