semaglutide doesn't seem to be working Why Am I Not Losing Weight on Ozempic? 4 Reasons You've been thinking about it,

Heres whats happening: as you lose weight, your body requires fewer calories to function

Researchers noted multiple study limitations, including use of records from health care organizations within the federated health research network TriNetX that may not be nationally representative, they wrote

Semaglutide was removed from the FDA's drug shortage list in February 2025, and tirzepatide followed in December 2024

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Capehorn MS, Catarig AM, Furberg JK, Janez A, Price HC, Tadayon S, Vergs B, Marre M

An evidence level has been assigned to each risk category, based on RCT and observational data, as well as NICE/SIGN guidelines and the licensed indication for each GLP-1 RA therapy