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The hepatoprotective effects observed in our study suggest that IF may offer additional benefits beyond inflammation control in patients with RA, potentially addressing comorbidities associated with metabolic dysfunction 16

Exposure to pesticides causes alteration of the inflammatory pathway (Nrf2/NF-kB, MAPKs/PI3K, and Akt/GSK3) reducing NF-E2related factor (Nrf)2, increasing NF-kB, and opening voltage-gated Ca2 + channel of the neurons plasmatic membrane (Silver et al., 2017), leading to oxidative stress, neuronal apoptosis e reduction of serotonin

ETM, elevated T-maze

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