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In a 23-week trial, subjects taking 1mg daily lost an average of 2.8kg compared to 0.8kg for placebo

Caroline Apovian of Brigham and Womens Hospital described the results as incredible, noting that the drugs effectiveness rivals the weight-loss benefits of surgery. Shares of Eli Lilly rose more than 3% after the announcement

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The studies identified the following effects relating to the therapeutic effects of GLP-1 RAs in PCOS animal models: metabolic effects (reduced body weight, improved insulin sensitivity, decreased HOMA-IR, and improved glucose tolerance), hormonal regulation (decreased testosterone, LH/FSH ratio, and increased SHBG) and ovarian effects (reduced cystic follicles, increased corpus luteum formation, and restored regular estrous cycles)