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[13] Fasting levels of insulin-like growth factor (IGF) binding proteins such as IGFBP1 and IGFBP2 increased after tirzepatide treatment, increasing insulin sensitivity

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However, the absence of a documented interaction does not necessarily establish the safety or efficacy of this combination

Impact on Appetite and Metabolism Tirzepatide significantly affects appetite regulation by stimulating the GIP and GLP-1 receptors in the brain, leading to a reduction in hunger and an increase in feelings of fullness