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It is very encouraging that continued treatment for four years or so is effective in helping people to lose weight at a clinically significant level of 10% on average, said Tricia Tan, professor of metabolic medicine and endocrinology at Imperial College London

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PMID: 32427345 Shapiro MJ, Blair MP, Solinski MA, Zhang DL, Jabbehdari S

They are often associated with hormonal fluctuations, particularly during puberty or menstrual cycles, and can be aggravated by certain skincare routines that do not adequately exfoliate the skin

,2010 Jan;7(1 Pt 1):269-76