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Wang H, Li L, Qin LL, et al

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Arch Intern Med 2006 Jun 26;166(12):1256-61

reported in an early study that Fas signaling stimulation did not lead to caspases recruitment in erythrocytes [182], it was later demonstrated that phosphatidylserine translocation to the outer membrane in RBCs was regulated by the assembly of the Fas/FADD/caspase-8 complex and downstream activation of caspase-3 [191]

Factors that may influence long-term outcomes include: Treatment duration and adaptation : Some patients report symptom improvement with continued therapy as the body adjusts Weight stabilisation : As weight loss plateaus, biomechanical stress on muscles and joints typically normalises Physical conditioning : Patients who maintain regular physical activity often experience better musculoskeletal health Nutritional optimisation : Addressing any dietary imbalances can support muscle and joint function For patients who continue to experience troublesome body aches despite conservative management, alternative strategies may be considered in consultation with healthcare professionals