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Understanding how these environmental variables contribute to ED could uncover new therapeutic targets and strategies for managing the condition through environmental interventions [7]

Thiele, J.J., Schroeter, C., Hsieh, S.N., Podda, M

Fitoterapia 82 (4), 513523

Specifically, HMGB1 secreted by breast cancer cells promotes fibroblast activation via the RAGE/aerobic glycolysis pathway, and these activated fibroblasts subsequently enhance breast cancer cell metastasis by increasing lactate production [240]

This technique can be implemented in simpler instruments, such as triple-quadrupole mass spectrometers (those most commonly used for organic analysis in forensic toxicology, in diagnostic clinical chemistry and in metabolomic studies), or in state-of-the-art dedicated instruments, known as Guided-Ion Beam Mass Spectrometer(s) (GIBMS) [109]