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Beside its role in oxidative metabolism, in the liver PGC-1 is mainly involved in de novo lipogenesis and hepatic triglycerides secretion through very low-density lipoproteins 14,15

Zhang, S., Liu, J., Dragunow, M

Conversely, silencing the Fetuin-A gene improves islet cell viability and glucose-stimulated insulin secretion [231]

These compounds undergo activation to toxic metabolites by numerous reactions, including glucuronidation by UGTs, acetylation by NATs, sulfonation by SULTs, and conjugation with amino acids by aminoacyltRNAsynthetase