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The L-carnitine-supplemented group showed a dose-dependent reduction in the levels of ACE2, TMPRSS2 and furin with the maximum effect observed at 200 mg/kg/day, which translates to 2,000 mg HED

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The most significant safety concern is effects on glucose metabolism: tesamorelin treatment increased fasting glucose levels, insulin levels, HbA1c, and incidence of new-onset diabetes or progression from prediabetes to diabetes significantly more than placebo