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In brief, the mice were administered a daily topical application of 62.5 mg of 5% imiquimod cream (Mingxinlidi, Sichuan, China) on their shaved backs for seven consecutive days

For severe reactions, hospital admission and treatment for skin failure is required

Currently, it has been reported that multiple regulatory mechanisms of ferroptosis mediate neuronal death, including iron overload, OS and neuro-inflammation

As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)

It can also improve immune system functioning and can help slow the signs of aging