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In T2D mouse models, sex-specific differences in GPER expression were observed, with female mice exhibiting significantly higher levels of GPER expression than male mice, while GPER expression decreased significantly following the induction of diabetes, implying that GPER expression influences the occurrence and development of diabetes

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Contraindications include personal or family history of medullary thyroid carcinoma, MEN2 syndrome, acute pancreatitis, or severe renal impairment

Patients with a documented history of ARF should receive antibiotic prophylaxis until the age of 21 or for a minimum of five years if there is no cardiac involvement