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Because the glucagon receptor is highly expressed in the liver, adding GCGR agonism gives the molecule a tissue-specific mechanism for reducing hepatic fat and, hypothetically, addressing the inflammation and fibrosis that define MASH

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GLP-1 is a hormone naturally secreted by the gastrointestinal tract following food intake, playing a critical role in regulating insulin secretion , glucose metabolism, appetite suppression, and gastric motility