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Abbreviations The following abbreviations are used in this manuscript: Author Contributions Z.W.: funding acquisition, investigation, conceptualization, and writingoriginal draft

However, when folate intake is low and/or alcohol intake is high, individuals with the (T/T) genotype have been found to be at increased risk of colorectal cancer (141, 142)

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In addition, it was confirmed that this NOX2 activity mainly occurs in the membrane, not in the cytoplasm

Percentage Moisture Loss To determine percentage moisture loss films of area 2 2 cm2 are cut and weighed accurately on an electronic balance