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While both act on melanocortin receptors, they are distinct compounds and are studied separately in research

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4,11,31 Concerning the development of multiple-site irAEs, the mean time since ICI initiation to their development was similar to single-site irAEs (62 vs 78 days, P = .414)

Metformin reduces blood sugar and increases insulin sensitivity by lowering the amount of glucose released into the bloodstream and increasing glucose uptake in skeletal muscle cells (18)