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Indeed, hyperprolactinemia could be determined not only by PRL-secreting pituitary adenomas, but also by numerous other conditions involving physiological status such as pregnancy and lactation, systemic disorders like chronic renal failure and cirrhosis or several pharmacological treatments ( Regardless of the nature of hyperprolactinemia ( Hyperprolactinemia has been associated with alterations in gluco-insulinemic metabolism ( Restoration of normal PRL levels through proper therapy has been demonstrated to improve metabolic impairment

Since the action of methylene blue is to oxidise NADPH, it is therefore likely that the pathway that results in decarboxylation is also the pathway that utilises NADP+ and forms NADPH

doi: 10.1091/mbc.e03-11-0786 46 Gonzalez-DonquilesCAlonso-MoleroJFernandez-VillaTVilorio-MarqusLMolinaAJMartnV

(71), study, which is restricted to the cohort of cases that were examined ( Table 1 )