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any given GPCR can interact with any G a subunit in its vicinity at any given time, but the interaction might be insufficient to result in nucleotide exchange, i.e., in G a activation

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Interestingly, the core region of the TMN, where the histaminergic neurons reside, does not express the long form of the leptin receptor (LepR) (135), which likely precludes direct effects of leptin on the histaminergic neurons themselves