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Substance P released in TBI or under stress, activates mast cells, microglia and astrocytes, and releases additional neuroinflammatory mediators that increase BBB permeability (Corrigan et al., 2016)

Review FRAT testing Screen the Pattern, Then Confirm Undermethylation and Mitochondrial Stress With Testing Symptoms can suggest possible undermethylation or mitochondrial stress, but laboratory findings help distinguish low SAM, elevated SAH, oxidative damage, copper-zinc imbalance, pyroluria and functional nutrient needs

If coffee feels harder to tolerate, you might try having it with food or adjusting the type (for example, cold brew vs

Moran LJ, Noakes M, Clifton PM, et al

When you combine results with a symptom diary and clinical expertise, you create a "big picture" view of your health