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The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)

Autophagy is a highly conserved catabolic process involving four key steps: initiation, autophagosome formation and maturation, fusion with lysosomes, and degradation of autophagic cargo

Cambridge: Elsevier (2017)

So for the most common long-term situation, an absorption problem, maintenance means one injection every two to three months rather than anything weekly or monthly