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It has a beneficial effect on the processes in the nervous system (synthesis of nucleic acids and the lipid composition of cerebrosides and phospholipids)

COSTA.IT 295 trial showed that although pioglitazone had no significant difference in total cardiovascular deaths compared with sulfonylureas in primary ASCVD diabetic patients, it significantly reduced the risk of ischemic cardiovascular events by 33%

7 Conclusions and discussion 7.1 Integrated mechanisms of the microbiota-gut-brain-immune axis in schizophrenia By integrating the evidence discussed throughout this review, we propose a comprehensive model illustrating the MGB-immune interactions in schizophrenia (See Figure 3 )

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doi: 10.3109/08820139.2012.692418 246 LiuJ.LiQ.WangC.ShaoJ.WangT.WuD.et al