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Effects of tirzepatide on cardiac injury and kidney function Treatment with tirzepatide resulted in a significant reduction in myocardial injury reflected by high-sensitivity troponin T as compared with placebo at both 24 and 52 weeks (ETD 24 weeks 9.8% (95% CI 16.0 to 3.3), P = 0.004, 52 weeks 10.4% (95% CI 16.7 to 3.6), P = 0.003), with no significant effect at 12 weeks (Fig