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[172] See also [edit] References [edit] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169083 Ensembl, May 2017 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046532 Ensembl, May 2017 "Human PubMed Reference:"

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doi: 10.1161/hypertensionaha.116.08526 211 GruneJBeyhoffNSmeirEChudekRBlumrichABanZet al

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The hallmark features of the subtype include higher expression of Ki67 (hence higher proliferation rate), lower expression of PR, and in some cases, positive status of HER2 and ER, a more aggressive phenotype with higher chances of early relapse, poor prognosis, lower survival rate, lymph node involvement, and metastasis ( 3.3 HER2 subtype This class of tumors is characterized by increased HER2 expression, while ER/PR expression is absent