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1,5-diCQA markedly reduced the mRNA expression of IL-1 and IL-6 on the ocular surface, encompassing the cornea and conjunctiva, as well as in the exorbital lacrimal gland [72]

2018a, 2018b)

Unlike human studies, where sampling tissues and biofluids are primarily limited to blood plasma, muscle, adipose, urine & fecal samples, mouse models allow researchers to sample multiple organs and tissues, often impossible due to ethical limitations in human volunteers

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It was developed by Metabolic Pharmaceuticals, an Australian biopharmaceutical company, in the late 1990s as a potential therapeutic for obesity and metabolic disorders