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10.1111/jdi.12956 127 YingX.RongjiongZ.KahaerM.ChunhuiJ.WulasihanM

While headline pharmaceutical research and development (R&D) returns have improved for the third consecutive year, reaching a 7.0 percent internal rate of return (IRR) in 2025, this recovery is largely driven by a few mega-blockbuster programs, notably glucagon-like peptide receptor agonists (GLP-1s) and GLP-1 combinations with gastric inhibitory polypeptide-based drugs (GIPs) in obesity, masking broader R&D pressures

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