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but a dose-dependent relationship

Many people can still lose weight in the 13001600 calorie range because GLP-1 medications reduce appetite and make smaller portions easier

To achieve proof of concept, we evaluated the capacity of cyclohepta[ b ]indoles to act as glucagon-like peptide-1 (GLP-1) secretagogues

The proportion of participants achieving clinically meaningful weight loss thresholds at 48 weeks on the 12 mg dose: - 5% weight loss: 100% - 10% weight loss: 93% - 15% weight loss: 83% For comparison, placebo achieved 5% in 27%, 10% in 9%, and 15% in just 2%

These FDA-approved injections, including Semaglutide GLP-1 and Tirzepatide , are proven to help with weight loss by regulating appetite, reducing hunger, and increasing fullness