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Preclinical study in mice with streptozotocin-induced diabetes that showed glucose-independent amelioration of kidney fibrosis with the DPP-4 inhibitor linagliptin

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Recommendations Choice of insulin regimen and preparation should be based upon cost, severity of hyperglycemia, risk of hypoglycemia, and likelihood of interventional procedure in near future (Grade B, EL II) Patients with T2DM on combination therapy of premixed insulin analogues and OADs should be carefully monitored for signs and symptoms of heart failure (HF), weight gain and edema, and a prompt clinical action is recommended if any deterioration in cardiac symptoms occurs (Grade B, EL II) Hepatic Impairment The patients with T2DM are at risk of developing non-alcoholic fatty liver disease (NAFLD) and therefore patients with diabetes and hepatic impairment are likely to be encountered in East Africa [114]