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27 assessed the QTc-prolonging and hemodynamic effects of a single dose of a bitter orange extract (Nature's Way) containing 27 mg p -synephrine (Table 1)

Mischley LK, Lau RC, Shankland EG, Wilbur TK, Padowski JM

In that same vein, the dose people respond to and tolerate without side effects is also individual. Babak Orandi, MD, PhD, obesity medicine specialist and transplant surgeon at the NYU Langone Weight Management Program, and associate professor in the Departments of Surgery and Medicine at NYU Grossman School of Medicine, said that for many doctors who prescribe this class of medications frequently, microdosing is something they have already been trying

That means Medicare will start covering obesity drugs for some patients for the first time starting mid-2026, a long-awaited move that could broaden the market for the medicines and spur more private insurers to cover them

Eur J Nutr 2012;51(1):1-18