Additional renal effects of hyperuricemia include metabolic acidosis caused by defective lactic acid excretion which in turn exacerbates the hyperuricemia due to reduced urate excretion
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Further, Xavier noted that she and her colleagues did not assess possible psychiatric side effects with these drugs in the studies they reviewed, so they could not say that these GLP-1 receptor agonists were completely safe in their own findings
Because poison center reports are voluntary and influenced by prescribing trends, media attention, and healthcare-seeking behavior, the findings cannot determine the true incidence of GLP-1 RA toxicity or establish causality
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