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Drug discontinuations due to side effects, primarily gastrointestinal, were slightly higher in the tirzepatide group (6.3% vs 1.4%)

Approximately, based on the SURPASS-2 trial where tirzepatide 5 mg was compared to semaglutide 1 mg

The pathophysiology involves sensitization of peripheral nociceptors and altered central nervous system processing of sensory information

The tradeoff is market access: a generic with a carved-out label cannot be substituted by pharmacists in all circumstances, since its approved indications are narrower than the brands

Since GLP-1 drugs also have an effect on inflammation and the immune system, combining them with biologics could create a heightened risk of infection or immune-related issues