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was supported by an American Diabetes Association Womens Health Career Development Award (9-24-JDFWH-01), a MGH Physician-Scientist Development Award, and the National Institutes of Health COURAGE grant (U24 DK132733)

The animal experiments and the in vitro, cell-based experiments were repeated at least twice

The transition to .5mg or higher typically brings more noticeable weight loss acceleration, with users reporting 510 pounds lost monthly once they reach therapeutic doses (1mg and above)

Despite extensive research into drug development for obesity and metabolic syndrome, success to date has primarily been limited to surgical interventions or treatment of associated risk factors

Understanding this mechanism is essential for both clinicians and patients, as it underscores that constipation is a predictable pharmacologic effect rather than an idiosyncratic reaction