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Troubleshoot adverse clinical observations Investigate hepatotoxicity observed in the clinic to establish the cause and inform go/no-go decision-making

doi: 10.3390/cimb44040096 366 PattersonETanHTTGroegerDAndrewsMBuckleyMMurphyEFet al

Depending on the chosen target(s), the review analyzed more than 80 distinctive targets, which were used in previous NO-agents studies with triple regimen, and the particular effectiveness of the given NO-agent(s) (aggravation (mostly L-NAME), protection (mostly L-arginine), and no effect (either L-NAME alone or L-arginine alone, or both, or combination L-NAME + L-arginine) [97]

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