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In a landmark study, Khavinson demonstrated that epitalon increased telomerase activity in human fibroblast cells, extending their proliferative lifespan from 34 passages to beyond 44 passages

This compound was originally approved by regulatory authorities in 1999, with the purpose to prevent kidney allograft rejection

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Claudin proteins are small (2027 kDa) transmembrane proteins expressed in tissue- and cell-specific manner, 12, 13 with a total of 27 claudin family members having been identified to date

In the subgroup analysis by outcome measures, the SMDs were -0.21 (95% CI