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NSAID Interference with Aspirin's Antiplatelet Effects As illustrated in Figure 3, non-aspirin NSAIDs can interfere with aspirin's ability to gain access to its COX-1 binding site by steric interference(2 drugs can't occupy the same active site at the same time), thus reducing aspirin's antiplatelet effects when the two drug types are taken concomitantly

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Obesity and cardiovascular disease: revisiting an old relationship