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To overcome these limitations, ongoing research into reducing these negative consequences and the creation of more affordable substitutes are essential

doi: 10.1128/MCB.00118-16

The need for indefinite medication continuation to maintain weight loss, along with associated costs and potential long-term safety concerns, must be factored into treatment decisions

Es decir, la poblacin ya tena un alto riesgo cardiovascular al enrolarse (aproximadamente 1 de cada 3 adultos con diabetes mellitus tipo 2 tambin tiene enfermedades cardiovasculares)