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Peeling off the layers: skin taping and a novel proteomics approach to study atopic dermatitis

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In TRIUMPH-1, people on the top 12 mg dose lost an average of 28.3% of their body weight over 80 weeks if they stayed on treatment, and 25.0%, including everyone who started

For cryo-EM analysis, SLC33A1 MAP was solubilized in 2% lauryl maltose neopentyl glycol (Anatrace, NG310), 0.2% cholesteryl hemisuccinate Tris salt (Anatrace, CH210), 50LmM HEPES (pH-adjusted with KOH, pHL7.4), 150LmM KCl supplemented with protease-inhibitor cocktail (1LmM phenylmethylsulfonyl fluoride (PMSF), 2.5LmgLml 1 aprotinin, 2.5LmgLml 1 leupeptin, 1LmgLml 1 pepstatin A) and DNase I