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All the patients fulfilled the criteria established by the American Society for Reproductive Medicine and the European Society for Human Reproduction and Embryology for diagnosing the presence of PCOS (20), and at least two of the following criteria had to be present: (a) oligomenorrhea with inter-menstrual intervals longer than 45 days, (b) clinical (acne, hirsutism) or biochemical signs of hyperandrogenism, (c) the presence of micro-polycystic ovaries at ultrasound
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The Oxford 2011 levels of evidence
DM is characterized by elevated blood sugar (glycemic) levels, therefore the role of these drugs is to reduce glycemic levels, possibly avoiding hypoglycemic events
More serious digestive complications, including pancreatitis, are considered possible but appear to be uncommon based on current research
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