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This could provide an explanation for why LPL preferentially hydrolyzes the sn-1 and sn-3 position on triglycerides, as in our modeling the sn-2 acyl chain interacts in a separate hydrophobic pocket, which could facilitate enhanced substrate recognition of the sn-1 or sn-3 position by the hydrophobic pore (Supplementary Fig

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Multiple observational studies and case reports suggest GLP-1 therapy may be safe in Type 1 diabetes when insulin doses are carefully adjusted under physician guidance

Ferroptosis is strikingly driven by worsening redox imbalance, which generates and maintains high levels of hydroperoxy-phospholipids (7, 24)

Nat Commun 2022;13:6318