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Then came the SOUL trial , which demonstrated that oral semaglutide also reduces MACE by 14% , establishing that the route of administration does not blunt the cardiovascular protection

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A meta-analysis of the effects of the current GLP-1RAs on body weight, glycemic control, and lipid profile revealed that tirzepatide, a dual GLP-1RA and GIP-RA, has the highest efficacy in improving glycemic control compared to other GLP-1RAs, suggesting a beneficial effect of targeting the GIP-R along with the GLP-1R

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