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Published preclinical research on FOXO4-DRI has demonstrated selective elimination of senescent cells in mouse models, with observed improvements in fitness markers, fur density, and organ function in aged subjects

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The molecule retains the complete 70-amino-acid native IGF-1 sequence with two structural modifications a 13-amino-acid N-terminal extension (the Long designation) and an arginine-for-glutamic-acid substitution at position 3 (the R3 designation) which together reduce binding affinity to circulating IGF binding proteins (IGFBPs) by approximately 600-fold while preserving full agonist activity at the IGF-1 receptor