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This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Basu et al., 2021)

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Some unusual symptoms, such as invasion of fat planes, heterogeneity, ill-defined margins, and edema surrounding the lesion, have been linked to MPNST [64]

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