Specifically, there was a median relative decrease in liver fat content measured by MRI-PDFF (15.7% to 9%, p = 0.006), and a reduction in median liver stiffness from 3.4 to 3.1 kPa (p = 0.049) assessed by MRE.66 A separate phase II, randomised, placebo-controlled trial evaluating GS-0976 in 127 subjects with NASH is underway to further assess safety and efficacy.67 Hyperimmune bovine colostrum has been demonstrated to regulate the body's immune response via induction of regulatory T cells, which in turn impact inflammation and insulin resistance.68 Data from an initial trial of 10 patients with NASH and insulin resistance treated with IMM-124E for 30 days resulted in improvements in insulin resistance and lipid profiles and increased levels of T regulatory cells.69 This is being further investigated in a randomised, placebo-controlled, phase II trial in 130 patients with NASH.70 Phase IIB: Aramchol Aramchol is a novel synthetic fatty acid/bile acid conjugate that impacts lipogenesis
Oakley AJ, Lo Bello M, Mazzetti AP, Federici G and Parker MW
Seek medical advice if you experience severe or worsening abdominal pain, persistent vomiting, signs of dehydration, blood in vomit or stools, severe constipation, or symptoms suggesting pancreatitis (severe upper abdominal pain radiating to the back)
Int J Epidemiol 48(5):16361649
Results are based on self-reported data from ~300,000 HealSend members on personalized treatment plans, including compounded GLP-1 medications and clinician consultations
